ANALYSIS OF PARB-CENTROMERE INTERACTIONS BY MULTIPLEX SPR IMAGING REVEALS SPECIFIC PATTERNS FOR BINDING PARB IN SIX CENTROMERES OF BURKHOLDERIALES CHROMOSOMES AND PLASMIDS.

Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids.The specific binding of ParB to parS modbiv nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons.Closely re

SCRAPPER, which is an F-box protein encoded by FBXL20, regulates the frequency of the miniature excitatory synaptic current through the ubiquitination of Rab3-interacting molecule 1.Here, we recorded the induction of long-term potentiation/depression (LTP/LTD) in CA3-CA1 synapses modbiv in E3 ubiquitin ligase SCRAPPER-deficient hippocampal slices.C

Background: Glaucoma is a chronic, progressive optic neuropathy caused by a group of ocular conditions which lead to damage of the optic nerve with progressive diminution of vision.Medical management is currently the primary line of treatment in primary open-angle glaucoma (POAG).Aim: pink chiclets gum The aim of this study was to determine the pat

Chromoanagenesis is a genomic catastrophe that results in chromosomal shattering and reassembly.These extreme single chromosome events were first identified in cancer, and have since been observed in other systems, but have so far only been formally documented in plants in the context of haploid induction crosses.The frequency, origins, consequence